Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study
Identifieur interne : 005461 ( Main/Exploration ); précédent : 005460; suivant : 005462Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study
Auteurs : A. Jakubowska [Pologne] ; D. Rozkrut [Pologne] ; A. Antoniou [Royaume-Uni] ; U. Hamann [Allemagne] ; R J Scott [Australie] ; L. Mcguffog [Royaume-Uni] ; S. Healy [Australie] ; O M Sinilnikova [France] ; G. Rennert [Israël] ; F. Lejbkowicz [Israël] ; A. Flugelman [Israël] ; I L Andrulis ; G. Glendon ; H. Ozcelik ; M. Thomassen [Danemark] ; M. Paligo [Italie] ; P. Aretini [Italie] ; J. Kantala [Suède] ; B. Aroer [Suède] ; A. Von Wachenfeldt [Suède] ; A. Liljegren [Suède] ; N. Loman [Suède] ; K. Herbst [Suède] ; U. Kristoffersson [Suède] ; R. Rosenquist [Suède] ; P. Karlsson [Suède] ; M. Stenmark-Askmalm [Suède] ; B. Melin [Suède] ; K L Nathanson [États-Unis] ; S M Domchek [États-Unis] ; T. Byrski [Pologne] ; T. Huzarski [Pologne] ; J. Gronwald [Pologne] ; J. Menkiszak [Pologne] ; C. Cybulski [Pologne] ; P. Serrano [Pologne] ; A. Osorio [Espagne] ; T R Cajal [Espagne] ; M. Tsitlaidou [Grèce] ; J. Benítez [Espagne] ; M. Gilbert [Allemagne] ; M. Rookus [Pays-Bas] ; C M Aalfs [Pays-Bas] ; I. Kluijt [Pays-Bas] ; J L Boessenkool-Pape [Pays-Bas] ; H E J. Meijers-Heijboer [Pays-Bas] ; J C Oosterwijk [Pays-Bas] ; C J Van Asperen [Pays-Bas] ; M J Blok [Pays-Bas] ; M R Nelen [Pays-Bas] ; A M W. Van Den Ouweland [Pays-Bas] ; C. Seynaeve [Pays-Bas] ; R B Van Der Luijt [Pays-Bas] ; P. Devilee [Pays-Bas] ; D F Easton [Royaume-Uni] ; S. Peock [Royaume-Uni] ; D. Frost [Royaume-Uni] ; R. Platte [Royaume-Uni] ; S D Ellis [Royaume-Uni] ; E. Fineberg [Royaume-Uni] ; D G Evans [Royaume-Uni] ; F. Lalloo [Royaume-Uni] ; R. Eeles [Royaume-Uni] ; C. Jacobs [Royaume-Uni] ; J. Adlard [Royaume-Uni] ; R. Davidson [Royaume-Uni] ; D. Eccles [Royaume-Uni] ; T. Cole [Royaume-Uni] ; J. Cook [Royaume-Uni] ; A. Godwin [États-Unis] ; B. Bove [États-Unis] ; D. Stoppa-Lyonnet [France] ; V. Caux-Moncoutier [France] ; M. Belotti [France] ; C. Tirapo [France] ; S. Mazoyer [France] ; L. Barjhoux [France] ; N. Boutry-Kryza [France] ; P. Pujol [France] ; I. Coupier [France] ; J-P Peyrat [France] ; P. Vennin [France] ; D. Muller [France] ; J-P Fricker [France] ; L. Venat-Bouvet [France] ; O Th Johannsson [Islande] ; C. Isaacs [États-Unis] ; R. Schmutzler [Allemagne] ; B. Wappenschmidt [Allemagne] ; A. Meindl [Allemagne] ; N. Arnold [Allemagne] ; R. Varon-Mateeva [Allemagne] ; D. Niederacher [Allemagne] ; C. Sutter [Allemagne] ; H. Deissler [Allemagne] ; S. Preisler-Adams [Allemagne] ; J. Simard [Canada] ; P. Soucy [Canada] ; F. Durocher [Canada] ; G. Chenevix-Trench [Australie] ; J. Beesley [Australie] ; X. Chen [Australie] ; T. Rebbeck [États-Unis] ; F. Couch [États-Unis] ; X. Wang [États-Unis] ; N. Lindor [États-Unis] ; Z. Fredericksen [États-Unis] ; V S Pankratz [États-Unis] ; P. Peterlongo [Italie] ; B. Bonanni [Italie] ; S. Fortuzzi [Italie] ; B. Peissel [Italie] ; C. Szabo [États-Unis] ; P L Mai [États-Unis] ; J T Loud [États-Unis] ; J. Lubinski [Pologne]Source :
- British Journal of Cancer [ 0007-0920 ] ; 2012.
Abstract
The variable penetrance of breast cancer in
To evaluate the potential role of genetic variants within
There was no evidence of association between the
The
Url:
DOI: 10.1038/bjc.2012.160
PubMed: 22669161
PubMed Central: 3388557
Affiliations:
- Allemagne, Australie, Canada, Danemark, Espagne, France, Grèce, Islande, Israël, Italie, Pays-Bas, Pologne, Royaume-Uni, Suède, États-Unis
Links toward previous steps (curation, corpus...)
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- to stream Main, to step Curation: 005461
Le document en format XML
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Rozkrut</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Statistics and Econometrics, School of Economics and Management, University of Szczecin</institution>, Szczecin,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Antoniou, A" sort="Antoniou, A" uniqKey="Antoniou A" first="A" last="Antoniou">A. Antoniou</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory</institution>, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hamann, U" sort="Hamann, U" uniqKey="Hamann U" first="U" last="Hamann">U. Hamann</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Functional Genome Analysis, Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ)</institution>, Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Scott, R J" sort="Scott, R J" uniqKey="Scott R" first="R J" last="Scott">R J Scott</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Department of Medical Genetics, Faculty of Health, University of Newcastle, and the Hunter Medical Research Institute</institution>, NSW,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mcguffog, L" sort="Mcguffog, L" uniqKey="Mcguffog L" first="L" last="Mcguffog">L. 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Healy</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Genetics and Population Health Division, Queensland Institute of Medical Research</institution>, Brisbane,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sinilnikova, O M" sort="Sinilnikova, O M" uniqKey="Sinilnikova O" first="O M" last="Sinilnikova">O M Sinilnikova</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard</institution>, Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon</institution>, Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rennert, G" sort="Rennert, G" uniqKey="Rennert G" first="G" last="Rennert">G. Rennert</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Department of Community Medicine and Epidemiology and Clalit National Cancer Control Center, Carmel Medical Center and B Rappaport Faculty of Medicine, Technion</institution>, Haifa,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lejbkowicz, F" sort="Lejbkowicz, F" uniqKey="Lejbkowicz F" first="F" last="Lejbkowicz">F. Lejbkowicz</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Department of Community Medicine and Epidemiology and Clalit National Cancer Control Center, Carmel Medical Center and B Rappaport Faculty of Medicine, Technion</institution>, Haifa,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Flugelman, A" sort="Flugelman, A" uniqKey="Flugelman A" first="A" last="Flugelman">A. Flugelman</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Department of Community Medicine and Epidemiology and Clalit National Cancer Control Center, Carmel Medical Center and B Rappaport Faculty of Medicine, Technion</institution>, Haifa,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Andrulis, I L" sort="Andrulis, I L" uniqKey="Andrulis I" first="I L" last="Andrulis">I L Andrulis</name><affiliation><nlm:aff id="aff11"><institution>Department of Molecular Genetics, Ontario Cancer Genetics Network, Cancer Care Ontario and Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>, Toronto,<country>Ontario</country></nlm:aff><wicri:noCountry code="nlm country">Ontario</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff12"><institution>Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>, Toronto,<country>Ontario</country></nlm:aff><wicri:noCountry code="nlm country">Ontario</wicri:noCountry></affiliation></author><author><name sortKey="Glendon, G" sort="Glendon, G" uniqKey="Glendon G" first="G" last="Glendon">G. Glendon</name><affiliation><nlm:aff id="aff11"><institution>Department of Molecular Genetics, Ontario Cancer Genetics Network, Cancer Care Ontario and Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>, Toronto,<country>Ontario</country></nlm:aff><wicri:noCountry code="nlm country">Ontario</wicri:noCountry></affiliation></author><author><name sortKey="Ozcelik, H" sort="Ozcelik, H" uniqKey="Ozcelik H" first="H" last="Ozcelik">H. Ozcelik</name><affiliation><nlm:aff id="aff12"><institution>Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>, Toronto,<country>Ontario</country></nlm:aff><wicri:noCountry code="nlm country">Ontario</wicri:noCountry></affiliation></author><author><name sortKey="Thomassen, M" sort="Thomassen, M" uniqKey="Thomassen M" first="M" last="Thomassen">M. Thomassen</name><affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Department of Clinical Genetics, Odense University Hospital</institution>, Odense,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Paligo, M" sort="Paligo, M" uniqKey="Paligo M" first="M" last="Paligo">M. Paligo</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Section of Genetic Oncology, University Hospital of Pisa</institution>, Pisa,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Aretini, P" sort="Aretini, P" uniqKey="Aretini P" first="P" last="Aretini">P. 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Aroer</name><affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Department of Oncology, Karolinska University Hospital</institution>, Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Von Wachenfeldt, A" sort="Von Wachenfeldt, A" uniqKey="Von Wachenfeldt A" first="A" last="Von Wachenfeldt">A. Von Wachenfeldt</name><affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Department of Oncology, Karolinska University Hospital</institution>, Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liljegren, A" sort="Liljegren, A" uniqKey="Liljegren A" first="A" last="Liljegren">A. Liljegren</name><affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Department of Oncology, Karolinska University Hospital</institution>, Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Loman, N" sort="Loman, N" uniqKey="Loman N" first="N" last="Loman">N. Loman</name><affiliation wicri:level="1"><nlm:aff id="aff18"><institution>Department of Oncology, Lund University Hospital</institution>, Lund,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Herbst, K" sort="Herbst, K" uniqKey="Herbst K" first="K" last="Herbst">K. Herbst</name><affiliation wicri:level="1"><nlm:aff id="aff18"><institution>Department of Oncology, Lund University Hospital</institution>, Lund,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kristoffersson, U" sort="Kristoffersson, U" uniqKey="Kristoffersson U" first="U" last="Kristoffersson">U. Kristoffersson</name><affiliation wicri:level="1"><nlm:aff id="aff19"><institution>Department of Clinical Genetics, Lund University Hospital</institution>, Lund,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rosenquist, R" sort="Rosenquist, R" uniqKey="Rosenquist R" first="R" last="Rosenquist">R. Rosenquist</name><affiliation wicri:level="1"><nlm:aff id="aff20"><institution>Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University</institution>, Uppsala,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Karlsson, P" sort="Karlsson, P" uniqKey="Karlsson P" first="P" last="Karlsson">P. Karlsson</name><affiliation wicri:level="1"><nlm:aff id="aff21"><institution>Department of Oncology, Sahlgrenska University Hospital</institution>, Gothenburg,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stenmark Askmalm, M" sort="Stenmark Askmalm, M" uniqKey="Stenmark Askmalm M" first="M" last="Stenmark-Askmalm">M. Stenmark-Askmalm</name><affiliation wicri:level="1"><nlm:aff id="aff22"><institution>Department of Oncology, University Hospital</institution>, Linköping<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Melin, B" sort="Melin, B" uniqKey="Melin B" first="B" last="Melin">B. Melin</name><affiliation wicri:level="1"><nlm:aff id="aff23"><institution>Department of Radiation Sciences, Oncology, Umeå University</institution>, Umeå,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nathanson, K L" sort="Nathanson, K L" uniqKey="Nathanson K" first="K L" last="Nathanson">K L Nathanson</name><affiliation wicri:level="1"><nlm:aff id="aff24"><institution>Department of Medicine and Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania</institution>, Philadelphia, PN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Domchek, S M" sort="Domchek, S M" uniqKey="Domchek S" first="S M" last="Domchek">S M Domchek</name><affiliation wicri:level="1"><nlm:aff id="aff24"><institution>Department of Medicine and Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania</institution>, Philadelphia, PN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Byrski, T" sort="Byrski, T" uniqKey="Byrski T" first="T" last="Byrski">T. Byrski</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Huzarski, T" sort="Huzarski, T" uniqKey="Huzarski T" first="T" last="Huzarski">T. Huzarski</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gronwald, J" sort="Gronwald, J" uniqKey="Gronwald J" first="J" last="Gronwald">J. Gronwald</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Menkiszak, J" sort="Menkiszak, J" uniqKey="Menkiszak J" first="J" last="Menkiszak">J. Menkiszak</name><affiliation wicri:level="1"><nlm:aff id="aff25"><institution>Chair and Department of Surgical Gynecology and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cybulski, C" sort="Cybulski, C" uniqKey="Cybulski C" first="C" last="Cybulski">C. Cybulski</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Serrano, P" sort="Serrano, P" uniqKey="Serrano P" first="P" last="Serrano">P. Serrano</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Osorio, A" sort="Osorio, A" uniqKey="Osorio A" first="A" last="Osorio">A. Osorio</name><affiliation wicri:level="1"><nlm:aff id="aff26"><institution>Human Genetics Group and Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre</institution>, Madrid,<country>Spain</country> (and Spanish Network on Rare Diseases (CIBERER))</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cajal, T R" sort="Cajal, T R" uniqKey="Cajal T" first="T R" last="Cajal">T R Cajal</name><affiliation wicri:level="1"><nlm:aff id="aff27"><institution>Oncology Service, Hospital de la Santa Creu i Sant Pau</institution>, Barcelona,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tsitlaidou, M" sort="Tsitlaidou, M" uniqKey="Tsitlaidou M" first="M" last="Tsitlaidou">M. Tsitlaidou</name><affiliation wicri:level="1"><nlm:aff id="aff28"><institution>Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research ‘Demokritos', Aghia Paraskevi Attikis</institution>, Athens 15310,<country>Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Benitez, J" sort="Benitez, J" uniqKey="Benitez J" first="J" last="Benítez">J. Benítez</name><affiliation wicri:level="1"><nlm:aff id="aff26"><institution>Human Genetics Group and Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre</institution>, Madrid,<country>Spain</country> (and Spanish Network on Rare Diseases (CIBERER))</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gilbert, M" sort="Gilbert, M" uniqKey="Gilbert M" first="M" last="Gilbert">M. Gilbert</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Functional Genome Analysis, Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ)</institution>, Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rookus, M" sort="Rookus, M" uniqKey="Rookus M" first="M" last="Rookus">M. Rookus</name><affiliation wicri:level="1"><nlm:aff id="aff29"><institution>Department of Epidemiology, Netherlands Cancer Institute</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Aalfs, C M" sort="Aalfs, C M" uniqKey="Aalfs C" first="C M" last="Aalfs">C M Aalfs</name><affiliation wicri:level="1"><nlm:aff id="aff30"><institution>Department of Clinical Genetics, Academic Medical Center</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kluijt, I" sort="Kluijt, I" uniqKey="Kluijt I" first="I" last="Kluijt">I. Kluijt</name><affiliation wicri:level="1"><nlm:aff id="aff31"><institution>Department of Family Cancer Clinic, Netherlands Cancer Institute</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boessenkool Pape, J L" sort="Boessenkool Pape, J L" uniqKey="Boessenkool Pape J" first="J L" last="Boessenkool-Pape">J L Boessenkool-Pape</name><affiliation wicri:level="1"><nlm:aff id="aff29"><institution>Department of Epidemiology, Netherlands Cancer Institute</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Meijers Heijboer, H E J" sort="Meijers Heijboer, H E J" uniqKey="Meijers Heijboer H" first="H E J" last="Meijers-Heijboer">H E J. Meijers-Heijboer</name><affiliation wicri:level="1"><nlm:aff id="aff32"><institution>Department of Clinical Genetics, VU Medical Center</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Oosterwijk, J C" sort="Oosterwijk, J C" uniqKey="Oosterwijk J" first="J C" last="Oosterwijk">J C Oosterwijk</name><affiliation wicri:level="1"><nlm:aff id="aff33"><institution>Department of Genetics, University Medical Center, Groningen University</institution>, Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Asperen, C J" sort="Van Asperen, C J" uniqKey="Van Asperen C" first="C J" last="Van Asperen">C J Van Asperen</name><affiliation wicri:level="1"><nlm:aff id="aff34"><institution>Department of Clinical Genetics Leiden University Medical Center Leiden</institution>, Leiden,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Blok, M J" sort="Blok, M J" uniqKey="Blok M" first="M J" last="Blok">M J Blok</name><affiliation wicri:level="1"><nlm:aff id="aff35"><institution>Department of Clinical Genetics, University Hospital Maastricht</institution>, Maastricht,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nelen, M R" sort="Nelen, M R" uniqKey="Nelen M" first="M R" last="Nelen">M R Nelen</name><affiliation wicri:level="1"><nlm:aff id="aff36"><institution>Department of Human Genetics 849, Radboud University Nijmegen Medical Centre</institution>, P.O. BOX 9101, HB Nijmegen, Nijmegen 6500,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Den Ouweland, A M W" sort="Van Den Ouweland, A M W" uniqKey="Van Den Ouweland A" first="A M W" last="Van Den Ouweland">A M W. Van Den Ouweland</name><affiliation wicri:level="1"><nlm:aff id="aff37"><institution>Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center</institution>, Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Seynaeve, C" sort="Seynaeve, C" uniqKey="Seynaeve C" first="C" last="Seynaeve">C. Seynaeve</name><affiliation wicri:level="1"><nlm:aff id="aff38"><institution>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center</institution>, Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Luijt, R B" sort="Van Der Luijt, R B" uniqKey="Van Der Luijt R" first="R B" last="Van Der Luijt">R B Van Der Luijt</name><affiliation wicri:level="1"><nlm:aff id="aff39"><institution>Department of Medical Genetics, University Medical Center Utrecht</institution>, Utrecht,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Devilee, P" sort="Devilee, P" uniqKey="Devilee P" first="P" last="Devilee">P. Devilee</name><affiliation wicri:level="1"><nlm:aff id="aff40"><institution>Department of Human Genetics & Department of Pathology, Leiden University Medical Center</institution>, Leiden,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Easton, D F" sort="Easton, D F" uniqKey="Easton D" first="D F" last="Easton">D F Easton</name><affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peock, S" sort="Peock, S" uniqKey="Peock S" first="S" last="Peock">S. Peock</name><affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Frost, D" sort="Frost, D" uniqKey="Frost D" first="D" last="Frost">D. Frost</name><affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Platte, R" sort="Platte, R" uniqKey="Platte R" first="R" last="Platte">R. Platte</name><affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ellis, S D" sort="Ellis, S D" uniqKey="Ellis S" first="S D" last="Ellis">S D Ellis</name><affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fineberg, E" sort="Fineberg, E" uniqKey="Fineberg E" first="E" last="Fineberg">E. Fineberg</name><affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Evans, D G" sort="Evans, D G" uniqKey="Evans D" first="D G" last="Evans">D G Evans</name><affiliation wicri:level="1"><nlm:aff id="aff42"><institution>Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust</institution>, Manchester,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lalloo, F" sort="Lalloo, F" uniqKey="Lalloo F" first="F" last="Lalloo">F. Lalloo</name><affiliation wicri:level="1"><nlm:aff id="aff42"><institution>Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust</institution>, Manchester,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eeles, R" sort="Eeles, R" uniqKey="Eeles R" first="R" last="Eeles">R. Eeles</name><affiliation wicri:level="1"><nlm:aff id="aff43"><institution>Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust</institution>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jacobs, C" sort="Jacobs, C" uniqKey="Jacobs C" first="C" last="Jacobs">C. Jacobs</name><affiliation wicri:level="1"><nlm:aff id="aff44"><institution>Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Adlard, J" sort="Adlard, J" uniqKey="Adlard J" first="J" last="Adlard">J. Adlard</name><affiliation wicri:level="1"><nlm:aff id="aff45"><institution>Yorkshire Regional Genetics Service</institution>, Leeds,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Davidson, R" sort="Davidson, R" uniqKey="Davidson R" first="R" last="Davidson">R. Davidson</name><affiliation wicri:level="1"><nlm:aff id="aff46"><institution>Ferguson-Smith Centre for Clinical Genetics, Yorkhill Hospitals</institution>, Glasgow,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eccles, D" sort="Eccles, D" uniqKey="Eccles D" first="D" last="Eccles">D. Eccles</name><affiliation wicri:level="1"><nlm:aff id="aff47"><institution>University of Southampton Faculty of Medicine, Southampton University Hospitals NHS Trust</institution>, Southampton,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cole, T" sort="Cole, T" uniqKey="Cole T" first="T" last="Cole">T. Cole</name><affiliation wicri:level="1"><nlm:aff id="aff48"><institution>West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust</institution>, Edgbaston, Birmingham,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cook, J" sort="Cook, J" uniqKey="Cook J" first="J" last="Cook">J. Cook</name><affiliation wicri:level="1"><nlm:aff id="aff49"><institution>Sheffield Clinical Genetics Service, Sheffield Children's Hospital</institution>, Sheffield,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Godwin, A" sort="Godwin, A" uniqKey="Godwin A" first="A" last="Godwin">A. Godwin</name><affiliation wicri:level="1"><nlm:aff id="aff50"><institution>Department of Pathology and Laboratory Medicine, the University of Kansas Medical Center</institution>, Kansas City, KS,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bove, B" sort="Bove, B" uniqKey="Bove B" first="B" last="Bove">B. Bove</name><affiliation wicri:level="1"><nlm:aff id="aff51"><institution>Clinical Molecular Genetics Laboratory, Fox Chase Cancer Center</institution>, Philadelphia, PA,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stoppa Lyonnet, D" sort="Stoppa Lyonnet, D" uniqKey="Stoppa Lyonnet D" first="D" last="Stoppa-Lyonnet">D. Stoppa-Lyonnet</name><affiliation wicri:level="1"><nlm:aff id="aff53"><institution>Service de Génétique Oncologique, Département de Biologie des Tumeurs, Institut Curie</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff54"><institution>Unité INSERM U830, Institut Curie</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff55"><institution>Université Paris Descartes, Faculté de Médecine</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Caux Moncoutier, V" sort="Caux Moncoutier, V" uniqKey="Caux Moncoutier V" first="V" last="Caux-Moncoutier">V. Caux-Moncoutier</name><affiliation wicri:level="1"><nlm:aff id="aff53"><institution>Service de Génétique Oncologique, Département de Biologie des Tumeurs, Institut Curie</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Belotti, M" sort="Belotti, M" uniqKey="Belotti M" first="M" last="Belotti">M. Belotti</name><affiliation wicri:level="1"><nlm:aff id="aff53"><institution>Service de Génétique Oncologique, Département de Biologie des Tumeurs, Institut Curie</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tirapo, C" sort="Tirapo, C" uniqKey="Tirapo C" first="C" last="Tirapo">C. Tirapo</name><affiliation wicri:level="1"><nlm:aff id="aff53"><institution>Service de Génétique Oncologique, Département de Biologie des Tumeurs, Institut Curie</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mazoyer, S" sort="Mazoyer, S" uniqKey="Mazoyer S" first="S" last="Mazoyer">S. Mazoyer</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon</institution>, Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barjhoux, L" sort="Barjhoux, L" uniqKey="Barjhoux L" first="L" last="Barjhoux">L. Barjhoux</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon</institution>, Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boutry Kryza, N" sort="Boutry Kryza, N" uniqKey="Boutry Kryza N" first="N" last="Boutry-Kryza">N. Boutry-Kryza</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard</institution>, Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pujol, P" sort="Pujol, P" uniqKey="Pujol P" first="P" last="Pujol">P. Pujol</name><affiliation wicri:level="1"><nlm:aff id="aff56"><institution>Unité d'Oncogénétique, CHU Arnaud de Villeneuve</institution>, Montpellier,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff57"><institution>INSERM 896, CRCM Val d'Aurelle</institution>, Montpellier,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Coupier, I" sort="Coupier, I" uniqKey="Coupier I" first="I" last="Coupier">I. Coupier</name><affiliation wicri:level="1"><nlm:aff id="aff56"><institution>Unité d'Oncogénétique, CHU Arnaud de Villeneuve</institution>, Montpellier,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff58"><institution>Unité d'Oncogénétique, CRLCC Val d'Aurelle</institution>, Montpellier,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peyrat, J P" sort="Peyrat, J P" uniqKey="Peyrat J" first="J-P" last="Peyrat">J-P Peyrat</name><affiliation wicri:level="1"><nlm:aff id="aff59"><institution>Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret</institution>, Lille,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vennin, P" sort="Vennin, P" uniqKey="Vennin P" first="P" last="Vennin">P. Vennin</name><affiliation wicri:level="1"><nlm:aff id="aff60"><institution>Consultation d'Oncogénétique, Centre Oscar Lambret</institution>, Lille,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Muller, D" sort="Muller, D" uniqKey="Muller D" first="D" last="Muller">D. Muller</name><affiliation wicri:level="1"><nlm:aff id="aff61"><institution>Unité d'Oncogénétique, CLCC Paul Strauss</institution>, Strasbourg,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fricker, J P" sort="Fricker, J P" uniqKey="Fricker J" first="J-P" last="Fricker">J-P Fricker</name><affiliation wicri:level="1"><nlm:aff id="aff61"><institution>Unité d'Oncogénétique, CLCC Paul Strauss</institution>, Strasbourg,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Venat Bouvet, L" sort="Venat Bouvet, L" uniqKey="Venat Bouvet L" first="L" last="Venat-Bouvet">L. Venat-Bouvet</name><affiliation wicri:level="1"><nlm:aff id="aff62"><institution>Department of Medical Oncology, Centre Hospitalier Universitaire Dupuytren</institution>, Limoges,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Johannsson, O Th" sort="Johannsson, O Th" uniqKey="Johannsson O" first="O Th" last="Johannsson">O Th Johannsson</name><affiliation wicri:level="1"><nlm:aff id="aff63"><institution>Department of Oncology, Landspitali University Hospital</institution>, Reykjavik,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff64"><institution>Faculity of Medicine, University of Iceland</institution>, Reykjavik,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Isaacs, C" sort="Isaacs, C" uniqKey="Isaacs C" first="C" last="Isaacs">C. Isaacs</name><affiliation wicri:level="1"><nlm:aff id="aff65"><institution>Department of Medicine and Oncology, Georgetown University</institution>, Washington, DC,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schmutzler, R" sort="Schmutzler, R" uniqKey="Schmutzler R" first="R" last="Schmutzler">R. Schmutzler</name><affiliation wicri:level="1"><nlm:aff id="aff66"><institution>Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne</institution>, Cologne,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wappenschmidt, B" sort="Wappenschmidt, B" uniqKey="Wappenschmidt B" first="B" last="Wappenschmidt">B. Wappenschmidt</name><affiliation wicri:level="1"><nlm:aff id="aff66"><institution>Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne</institution>, Cologne,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Meindl, A" sort="Meindl, A" uniqKey="Meindl A" first="A" last="Meindl">A. Meindl</name><affiliation wicri:level="1"><nlm:aff id="aff67"><institution>Department of Gynaecology and Obstetrics, Ludwig-Maximillians University Munich</institution>, Munich,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Arnold, N" sort="Arnold, N" uniqKey="Arnold N" first="N" last="Arnold">N. Arnold</name><affiliation wicri:level="1"><nlm:aff id="aff68"><institution>Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University</institution>, Kiel,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Varon Mateeva, R" sort="Varon Mateeva, R" uniqKey="Varon Mateeva R" first="R" last="Varon-Mateeva">R. Varon-Mateeva</name><affiliation wicri:level="1"><nlm:aff id="aff69"><institution>Institute of Human Genetics, Campus Virchov Klinikum</institution>, Charite Berlin,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Niederacher, D" sort="Niederacher, D" uniqKey="Niederacher D" first="D" last="Niederacher">D. Niederacher</name><affiliation wicri:level="1"><nlm:aff id="aff70"><institution>Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University</institution>, Düsseldorf,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sutter, C" sort="Sutter, C" uniqKey="Sutter C" first="C" last="Sutter">C. Sutter</name><affiliation wicri:level="1"><nlm:aff id="aff71"><institution>Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg</institution>, Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deissler, H" sort="Deissler, H" uniqKey="Deissler H" first="H" last="Deissler">H. Deissler</name><affiliation wicri:level="1"><nlm:aff id="aff72"><institution>Department of Gynaecology and Obstetrics, University Hospital</institution>, Ulm,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Preisler Adams, S" sort="Preisler Adams, S" uniqKey="Preisler Adams S" first="S" last="Preisler-Adams">S. Preisler-Adams</name><affiliation wicri:level="1"><nlm:aff id="aff73"><institution>Institute of Human Genetics, University of Münster</institution>, Münster,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Simard, J" sort="Simard, J" uniqKey="Simard J" first="J" last="Simard">J. Simard</name><affiliation wicri:level="1"><nlm:aff id="aff74"><institution>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University</institution>, Quebec,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Soucy, P" sort="Soucy, P" uniqKey="Soucy P" first="P" last="Soucy">P. Soucy</name><affiliation wicri:level="1"><nlm:aff id="aff74"><institution>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University</institution>, Quebec,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Durocher, F" sort="Durocher, F" uniqKey="Durocher F" first="F" last="Durocher">F. Durocher</name><affiliation wicri:level="1"><nlm:aff id="aff74"><institution>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University</institution>, Quebec,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chenevix Trench, G" sort="Chenevix Trench, G" uniqKey="Chenevix Trench G" first="G" last="Chenevix-Trench">G. Chenevix-Trench</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Genetics and Population Health Division, Queensland Institute of Medical Research</institution>, Brisbane,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Beesley, J" sort="Beesley, J" uniqKey="Beesley J" first="J" last="Beesley">J. Beesley</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Genetics and Population Health Division, Queensland Institute of Medical Research</institution>, Brisbane,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, X" sort="Chen, X" uniqKey="Chen X" first="X" last="Chen">X. Chen</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Genetics and Population Health Division, Queensland Institute of Medical Research</institution>, Brisbane,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rebbeck, T" sort="Rebbeck, T" uniqKey="Rebbeck T" first="T" last="Rebbeck">T. Rebbeck</name><affiliation wicri:level="1"><nlm:aff id="aff76"><institution>Department of Biostatistics and Epidemiology, Perelman School of Medicine and Abramson Cancer Center, University of Pennsylvania</institution>, Philadelphia, PA,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Couch, F" sort="Couch, F" uniqKey="Couch F" first="F" last="Couch">F. Couch</name><affiliation wicri:level="1"><nlm:aff id="aff77"><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff78"><institution>Department of Health Sciences Research, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, X" sort="Wang, X" uniqKey="Wang X" first="X" last="Wang">X. Wang</name><affiliation wicri:level="1"><nlm:aff id="aff77"><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lindor, N" sort="Lindor, N" uniqKey="Lindor N" first="N" last="Lindor">N. Lindor</name><affiliation wicri:level="1"><nlm:aff id="aff79"><institution>Department of Medical Genetics, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fredericksen, Z" sort="Fredericksen, Z" uniqKey="Fredericksen Z" first="Z" last="Fredericksen">Z. Fredericksen</name><affiliation wicri:level="1"><nlm:aff id="aff78"><institution>Department of Health Sciences Research, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pankratz, V S" sort="Pankratz, V S" uniqKey="Pankratz V" first="V S" last="Pankratz">V S Pankratz</name><affiliation wicri:level="1"><nlm:aff id="aff78"><institution>Department of Health Sciences Research, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peterlongo, P" sort="Peterlongo, P" uniqKey="Peterlongo P" first="P" last="Peterlongo">P. Peterlongo</name><affiliation wicri:level="1"><nlm:aff id="aff80"><institution>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predicted Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT)</institution>, Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff81"><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>, Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bonanni, B" sort="Bonanni, B" uniqKey="Bonanni B" first="B" last="Bonanni">B. Bonanni</name><affiliation wicri:level="1"><nlm:aff id="aff82"><institution>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia</institution>, Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fortuzzi, S" sort="Fortuzzi, S" uniqKey="Fortuzzi S" first="S" last="Fortuzzi">S. Fortuzzi</name><affiliation wicri:level="1"><nlm:aff id="aff83"><institution>82-IFOM, Fondazione Istituto FIRC di Oncologia Molecolare and 84-Cogentech Cancer Genetic Test Laboratory</institution>, Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peissel, B" sort="Peissel, B" uniqKey="Peissel B" first="B" last="Peissel">B. Peissel</name><affiliation wicri:level="1"><nlm:aff id="aff84"><institution>Unit of Medical Genetics, Department of Preventive and Preventive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT)</institution>, Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Szabo, C" sort="Szabo, C" uniqKey="Szabo C" first="C" last="Szabo">C. Szabo</name><affiliation wicri:level="1"><nlm:aff id="aff85"><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine</institution>, Rochester, MN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mai, P L" sort="Mai, P L" uniqKey="Mai P" first="P L" last="Mai">P L Mai</name><affiliation wicri:level="1"><nlm:aff id="aff86"><institution>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services</institution>, 6120 Executive Boulelvard, Rockville, MD 20852,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Loud, J T" sort="Loud, J T" uniqKey="Loud J" first="J T" last="Loud">J T Loud</name><affiliation wicri:level="1"><nlm:aff id="aff86"><institution>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services</institution>, 6120 Executive Boulelvard, Rockville, MD 20852,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lubinski, J" sort="Lubinski, J" uniqKey="Lubinski J" first="J" last="Lubinski">J. Lubinski</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22669161</idno><idno type="pmc">3388557</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388557</idno><idno type="RBID">PMC:3388557</idno><idno type="doi">10.1038/bjc.2012.160</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000078</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000078</idno><idno type="wicri:Area/Pmc/Curation">000078</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000078</idno><idno type="wicri:Area/Pmc/Checkpoint">002048</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002048</idno><idno type="wicri:Area/Ncbi/Merge">000E47</idno><idno type="wicri:Area/Ncbi/Curation">000E47</idno><idno type="wicri:Area/Ncbi/Checkpoint">000E47</idno><idno type="wicri:doubleKey">0007-0920:2012:Jakubowska A:association:of:phb</idno><idno type="wicri:Area/Main/Merge">005723</idno><idno type="wicri:Area/Main/Curation">005461</idno><idno type="wicri:Area/Main/Exploration">005461</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study</title><author><name sortKey="Jakubowska, A" sort="Jakubowska, A" uniqKey="Jakubowska A" first="A" last="Jakubowska">A. Jakubowska</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rozkrut, D" sort="Rozkrut, D" uniqKey="Rozkrut D" first="D" last="Rozkrut">D. Rozkrut</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Statistics and Econometrics, School of Economics and Management, University of Szczecin</institution>, Szczecin,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Antoniou, A" sort="Antoniou, A" uniqKey="Antoniou A" first="A" last="Antoniou">A. Antoniou</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory</institution>, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hamann, U" sort="Hamann, U" uniqKey="Hamann U" first="U" last="Hamann">U. Hamann</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Functional Genome Analysis, Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ)</institution>, Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Scott, R J" sort="Scott, R J" uniqKey="Scott R" first="R J" last="Scott">R J Scott</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Department of Medical Genetics, Faculty of Health, University of Newcastle, and the Hunter Medical Research Institute</institution>, NSW,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mcguffog, L" sort="Mcguffog, L" uniqKey="Mcguffog L" first="L" last="Mcguffog">L. Mcguffog</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Healy, S" sort="Healy, S" uniqKey="Healy S" first="S" last="Healy">S. Healy</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Genetics and Population Health Division, Queensland Institute of Medical Research</institution>, Brisbane,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sinilnikova, O M" sort="Sinilnikova, O M" uniqKey="Sinilnikova O" first="O M" last="Sinilnikova">O M Sinilnikova</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard</institution>, Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon</institution>, Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rennert, G" sort="Rennert, G" uniqKey="Rennert G" first="G" last="Rennert">G. Rennert</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Department of Community Medicine and Epidemiology and Clalit National Cancer Control Center, Carmel Medical Center and B Rappaport Faculty of Medicine, Technion</institution>, Haifa,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lejbkowicz, F" sort="Lejbkowicz, F" uniqKey="Lejbkowicz F" first="F" last="Lejbkowicz">F. Lejbkowicz</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Department of Community Medicine and Epidemiology and Clalit National Cancer Control Center, Carmel Medical Center and B Rappaport Faculty of Medicine, Technion</institution>, Haifa,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Flugelman, A" sort="Flugelman, A" uniqKey="Flugelman A" first="A" last="Flugelman">A. Flugelman</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Department of Community Medicine and Epidemiology and Clalit National Cancer Control Center, Carmel Medical Center and B Rappaport Faculty of Medicine, Technion</institution>, Haifa,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Andrulis, I L" sort="Andrulis, I L" uniqKey="Andrulis I" first="I L" last="Andrulis">I L Andrulis</name><affiliation><nlm:aff id="aff11"><institution>Department of Molecular Genetics, Ontario Cancer Genetics Network, Cancer Care Ontario and Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>, Toronto,<country>Ontario</country></nlm:aff><wicri:noCountry code="nlm country">Ontario</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff12"><institution>Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>, Toronto,<country>Ontario</country></nlm:aff><wicri:noCountry code="nlm country">Ontario</wicri:noCountry></affiliation></author><author><name sortKey="Glendon, G" sort="Glendon, G" uniqKey="Glendon G" first="G" last="Glendon">G. Glendon</name><affiliation><nlm:aff id="aff11"><institution>Department of Molecular Genetics, Ontario Cancer Genetics Network, Cancer Care Ontario and Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>, Toronto,<country>Ontario</country></nlm:aff><wicri:noCountry code="nlm country">Ontario</wicri:noCountry></affiliation></author><author><name sortKey="Ozcelik, H" sort="Ozcelik, H" uniqKey="Ozcelik H" first="H" last="Ozcelik">H. Ozcelik</name><affiliation><nlm:aff id="aff12"><institution>Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>, Toronto,<country>Ontario</country></nlm:aff><wicri:noCountry code="nlm country">Ontario</wicri:noCountry></affiliation></author><author><name sortKey="Thomassen, M" sort="Thomassen, M" uniqKey="Thomassen M" first="M" last="Thomassen">M. Thomassen</name><affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Department of Clinical Genetics, Odense University Hospital</institution>, Odense,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Paligo, M" sort="Paligo, M" uniqKey="Paligo M" first="M" last="Paligo">M. Paligo</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Section of Genetic Oncology, University Hospital of Pisa</institution>, Pisa,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Aretini, P" sort="Aretini, P" uniqKey="Aretini P" first="P" last="Aretini">P. Aretini</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Section of Genetic Oncology, University Hospital of Pisa</institution>, Pisa,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kantala, J" sort="Kantala, J" uniqKey="Kantala J" first="J" last="Kantala">J. Kantala</name><affiliation wicri:level="1"><nlm:aff id="aff16"><institution>Department of Clinical Genetics, Karolinska University Hospital</institution>, Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Aroer, B" sort="Aroer, B" uniqKey="Aroer B" first="B" last="Aroer">B. Aroer</name><affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Department of Oncology, Karolinska University Hospital</institution>, Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Von Wachenfeldt, A" sort="Von Wachenfeldt, A" uniqKey="Von Wachenfeldt A" first="A" last="Von Wachenfeldt">A. Von Wachenfeldt</name><affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Department of Oncology, Karolinska University Hospital</institution>, Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liljegren, A" sort="Liljegren, A" uniqKey="Liljegren A" first="A" last="Liljegren">A. Liljegren</name><affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Department of Oncology, Karolinska University Hospital</institution>, Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Loman, N" sort="Loman, N" uniqKey="Loman N" first="N" last="Loman">N. Loman</name><affiliation wicri:level="1"><nlm:aff id="aff18"><institution>Department of Oncology, Lund University Hospital</institution>, Lund,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Herbst, K" sort="Herbst, K" uniqKey="Herbst K" first="K" last="Herbst">K. Herbst</name><affiliation wicri:level="1"><nlm:aff id="aff18"><institution>Department of Oncology, Lund University Hospital</institution>, Lund,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kristoffersson, U" sort="Kristoffersson, U" uniqKey="Kristoffersson U" first="U" last="Kristoffersson">U. Kristoffersson</name><affiliation wicri:level="1"><nlm:aff id="aff19"><institution>Department of Clinical Genetics, Lund University Hospital</institution>, Lund,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rosenquist, R" sort="Rosenquist, R" uniqKey="Rosenquist R" first="R" last="Rosenquist">R. Rosenquist</name><affiliation wicri:level="1"><nlm:aff id="aff20"><institution>Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University</institution>, Uppsala,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Karlsson, P" sort="Karlsson, P" uniqKey="Karlsson P" first="P" last="Karlsson">P. Karlsson</name><affiliation wicri:level="1"><nlm:aff id="aff21"><institution>Department of Oncology, Sahlgrenska University Hospital</institution>, Gothenburg,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stenmark Askmalm, M" sort="Stenmark Askmalm, M" uniqKey="Stenmark Askmalm M" first="M" last="Stenmark-Askmalm">M. Stenmark-Askmalm</name><affiliation wicri:level="1"><nlm:aff id="aff22"><institution>Department of Oncology, University Hospital</institution>, Linköping<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Melin, B" sort="Melin, B" uniqKey="Melin B" first="B" last="Melin">B. Melin</name><affiliation wicri:level="1"><nlm:aff id="aff23"><institution>Department of Radiation Sciences, Oncology, Umeå University</institution>, Umeå,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nathanson, K L" sort="Nathanson, K L" uniqKey="Nathanson K" first="K L" last="Nathanson">K L Nathanson</name><affiliation wicri:level="1"><nlm:aff id="aff24"><institution>Department of Medicine and Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania</institution>, Philadelphia, PN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Domchek, S M" sort="Domchek, S M" uniqKey="Domchek S" first="S M" last="Domchek">S M Domchek</name><affiliation wicri:level="1"><nlm:aff id="aff24"><institution>Department of Medicine and Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania</institution>, Philadelphia, PN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Byrski, T" sort="Byrski, T" uniqKey="Byrski T" first="T" last="Byrski">T. Byrski</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Huzarski, T" sort="Huzarski, T" uniqKey="Huzarski T" first="T" last="Huzarski">T. Huzarski</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gronwald, J" sort="Gronwald, J" uniqKey="Gronwald J" first="J" last="Gronwald">J. Gronwald</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Menkiszak, J" sort="Menkiszak, J" uniqKey="Menkiszak J" first="J" last="Menkiszak">J. Menkiszak</name><affiliation wicri:level="1"><nlm:aff id="aff25"><institution>Chair and Department of Surgical Gynecology and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cybulski, C" sort="Cybulski, C" uniqKey="Cybulski C" first="C" last="Cybulski">C. Cybulski</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Serrano, P" sort="Serrano, P" uniqKey="Serrano P" first="P" last="Serrano">P. Serrano</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Osorio, A" sort="Osorio, A" uniqKey="Osorio A" first="A" last="Osorio">A. Osorio</name><affiliation wicri:level="1"><nlm:aff id="aff26"><institution>Human Genetics Group and Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre</institution>, Madrid,<country>Spain</country> (and Spanish Network on Rare Diseases (CIBERER))</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cajal, T R" sort="Cajal, T R" uniqKey="Cajal T" first="T R" last="Cajal">T R Cajal</name><affiliation wicri:level="1"><nlm:aff id="aff27"><institution>Oncology Service, Hospital de la Santa Creu i Sant Pau</institution>, Barcelona,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tsitlaidou, M" sort="Tsitlaidou, M" uniqKey="Tsitlaidou M" first="M" last="Tsitlaidou">M. Tsitlaidou</name><affiliation wicri:level="1"><nlm:aff id="aff28"><institution>Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research ‘Demokritos', Aghia Paraskevi Attikis</institution>, Athens 15310,<country>Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Benitez, J" sort="Benitez, J" uniqKey="Benitez J" first="J" last="Benítez">J. Benítez</name><affiliation wicri:level="1"><nlm:aff id="aff26"><institution>Human Genetics Group and Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre</institution>, Madrid,<country>Spain</country> (and Spanish Network on Rare Diseases (CIBERER))</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gilbert, M" sort="Gilbert, M" uniqKey="Gilbert M" first="M" last="Gilbert">M. Gilbert</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Functional Genome Analysis, Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ)</institution>, Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rookus, M" sort="Rookus, M" uniqKey="Rookus M" first="M" last="Rookus">M. Rookus</name><affiliation wicri:level="1"><nlm:aff id="aff29"><institution>Department of Epidemiology, Netherlands Cancer Institute</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Aalfs, C M" sort="Aalfs, C M" uniqKey="Aalfs C" first="C M" last="Aalfs">C M Aalfs</name><affiliation wicri:level="1"><nlm:aff id="aff30"><institution>Department of Clinical Genetics, Academic Medical Center</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kluijt, I" sort="Kluijt, I" uniqKey="Kluijt I" first="I" last="Kluijt">I. Kluijt</name><affiliation wicri:level="1"><nlm:aff id="aff31"><institution>Department of Family Cancer Clinic, Netherlands Cancer Institute</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boessenkool Pape, J L" sort="Boessenkool Pape, J L" uniqKey="Boessenkool Pape J" first="J L" last="Boessenkool-Pape">J L Boessenkool-Pape</name><affiliation wicri:level="1"><nlm:aff id="aff29"><institution>Department of Epidemiology, Netherlands Cancer Institute</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Meijers Heijboer, H E J" sort="Meijers Heijboer, H E J" uniqKey="Meijers Heijboer H" first="H E J" last="Meijers-Heijboer">H E J. Meijers-Heijboer</name><affiliation wicri:level="1"><nlm:aff id="aff32"><institution>Department of Clinical Genetics, VU Medical Center</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Oosterwijk, J C" sort="Oosterwijk, J C" uniqKey="Oosterwijk J" first="J C" last="Oosterwijk">J C Oosterwijk</name><affiliation wicri:level="1"><nlm:aff id="aff33"><institution>Department of Genetics, University Medical Center, Groningen University</institution>, Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Asperen, C J" sort="Van Asperen, C J" uniqKey="Van Asperen C" first="C J" last="Van Asperen">C J Van Asperen</name><affiliation wicri:level="1"><nlm:aff id="aff34"><institution>Department of Clinical Genetics Leiden University Medical Center Leiden</institution>, Leiden,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Blok, M J" sort="Blok, M J" uniqKey="Blok M" first="M J" last="Blok">M J Blok</name><affiliation wicri:level="1"><nlm:aff id="aff35"><institution>Department of Clinical Genetics, University Hospital Maastricht</institution>, Maastricht,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nelen, M R" sort="Nelen, M R" uniqKey="Nelen M" first="M R" last="Nelen">M R Nelen</name><affiliation wicri:level="1"><nlm:aff id="aff36"><institution>Department of Human Genetics 849, Radboud University Nijmegen Medical Centre</institution>, P.O. BOX 9101, HB Nijmegen, Nijmegen 6500,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Den Ouweland, A M W" sort="Van Den Ouweland, A M W" uniqKey="Van Den Ouweland A" first="A M W" last="Van Den Ouweland">A M W. Van Den Ouweland</name><affiliation wicri:level="1"><nlm:aff id="aff37"><institution>Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center</institution>, Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Seynaeve, C" sort="Seynaeve, C" uniqKey="Seynaeve C" first="C" last="Seynaeve">C. Seynaeve</name><affiliation wicri:level="1"><nlm:aff id="aff38"><institution>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center</institution>, Rotterdam,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Luijt, R B" sort="Van Der Luijt, R B" uniqKey="Van Der Luijt R" first="R B" last="Van Der Luijt">R B Van Der Luijt</name><affiliation wicri:level="1"><nlm:aff id="aff39"><institution>Department of Medical Genetics, University Medical Center Utrecht</institution>, Utrecht,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Devilee, P" sort="Devilee, P" uniqKey="Devilee P" first="P" last="Devilee">P. Devilee</name><affiliation wicri:level="1"><nlm:aff id="aff40"><institution>Department of Human Genetics & Department of Pathology, Leiden University Medical Center</institution>, Leiden,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Easton, D F" sort="Easton, D F" uniqKey="Easton D" first="D F" last="Easton">D F Easton</name><affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peock, S" sort="Peock, S" uniqKey="Peock S" first="S" last="Peock">S. Peock</name><affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Frost, D" sort="Frost, D" uniqKey="Frost D" first="D" last="Frost">D. Frost</name><affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Platte, R" sort="Platte, R" uniqKey="Platte R" first="R" last="Platte">R. Platte</name><affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ellis, S D" sort="Ellis, S D" uniqKey="Ellis S" first="S D" last="Ellis">S D Ellis</name><affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fineberg, E" sort="Fineberg, E" uniqKey="Fineberg E" first="E" last="Fineberg">E. Fineberg</name><affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>, Cambridge,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Evans, D G" sort="Evans, D G" uniqKey="Evans D" first="D G" last="Evans">D G Evans</name><affiliation wicri:level="1"><nlm:aff id="aff42"><institution>Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust</institution>, Manchester,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lalloo, F" sort="Lalloo, F" uniqKey="Lalloo F" first="F" last="Lalloo">F. Lalloo</name><affiliation wicri:level="1"><nlm:aff id="aff42"><institution>Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust</institution>, Manchester,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eeles, R" sort="Eeles, R" uniqKey="Eeles R" first="R" last="Eeles">R. Eeles</name><affiliation wicri:level="1"><nlm:aff id="aff43"><institution>Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust</institution>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jacobs, C" sort="Jacobs, C" uniqKey="Jacobs C" first="C" last="Jacobs">C. Jacobs</name><affiliation wicri:level="1"><nlm:aff id="aff44"><institution>Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Adlard, J" sort="Adlard, J" uniqKey="Adlard J" first="J" last="Adlard">J. Adlard</name><affiliation wicri:level="1"><nlm:aff id="aff45"><institution>Yorkshire Regional Genetics Service</institution>, Leeds,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Davidson, R" sort="Davidson, R" uniqKey="Davidson R" first="R" last="Davidson">R. Davidson</name><affiliation wicri:level="1"><nlm:aff id="aff46"><institution>Ferguson-Smith Centre for Clinical Genetics, Yorkhill Hospitals</institution>, Glasgow,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eccles, D" sort="Eccles, D" uniqKey="Eccles D" first="D" last="Eccles">D. Eccles</name><affiliation wicri:level="1"><nlm:aff id="aff47"><institution>University of Southampton Faculty of Medicine, Southampton University Hospitals NHS Trust</institution>, Southampton,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cole, T" sort="Cole, T" uniqKey="Cole T" first="T" last="Cole">T. Cole</name><affiliation wicri:level="1"><nlm:aff id="aff48"><institution>West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust</institution>, Edgbaston, Birmingham,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cook, J" sort="Cook, J" uniqKey="Cook J" first="J" last="Cook">J. Cook</name><affiliation wicri:level="1"><nlm:aff id="aff49"><institution>Sheffield Clinical Genetics Service, Sheffield Children's Hospital</institution>, Sheffield,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Godwin, A" sort="Godwin, A" uniqKey="Godwin A" first="A" last="Godwin">A. Godwin</name><affiliation wicri:level="1"><nlm:aff id="aff50"><institution>Department of Pathology and Laboratory Medicine, the University of Kansas Medical Center</institution>, Kansas City, KS,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bove, B" sort="Bove, B" uniqKey="Bove B" first="B" last="Bove">B. Bove</name><affiliation wicri:level="1"><nlm:aff id="aff51"><institution>Clinical Molecular Genetics Laboratory, Fox Chase Cancer Center</institution>, Philadelphia, PA,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stoppa Lyonnet, D" sort="Stoppa Lyonnet, D" uniqKey="Stoppa Lyonnet D" first="D" last="Stoppa-Lyonnet">D. Stoppa-Lyonnet</name><affiliation wicri:level="1"><nlm:aff id="aff53"><institution>Service de Génétique Oncologique, Département de Biologie des Tumeurs, Institut Curie</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff54"><institution>Unité INSERM U830, Institut Curie</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff55"><institution>Université Paris Descartes, Faculté de Médecine</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Caux Moncoutier, V" sort="Caux Moncoutier, V" uniqKey="Caux Moncoutier V" first="V" last="Caux-Moncoutier">V. Caux-Moncoutier</name><affiliation wicri:level="1"><nlm:aff id="aff53"><institution>Service de Génétique Oncologique, Département de Biologie des Tumeurs, Institut Curie</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Belotti, M" sort="Belotti, M" uniqKey="Belotti M" first="M" last="Belotti">M. Belotti</name><affiliation wicri:level="1"><nlm:aff id="aff53"><institution>Service de Génétique Oncologique, Département de Biologie des Tumeurs, Institut Curie</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tirapo, C" sort="Tirapo, C" uniqKey="Tirapo C" first="C" last="Tirapo">C. Tirapo</name><affiliation wicri:level="1"><nlm:aff id="aff53"><institution>Service de Génétique Oncologique, Département de Biologie des Tumeurs, Institut Curie</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mazoyer, S" sort="Mazoyer, S" uniqKey="Mazoyer S" first="S" last="Mazoyer">S. Mazoyer</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon</institution>, Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barjhoux, L" sort="Barjhoux, L" uniqKey="Barjhoux L" first="L" last="Barjhoux">L. Barjhoux</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon</institution>, Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boutry Kryza, N" sort="Boutry Kryza, N" uniqKey="Boutry Kryza N" first="N" last="Boutry-Kryza">N. Boutry-Kryza</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard</institution>, Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pujol, P" sort="Pujol, P" uniqKey="Pujol P" first="P" last="Pujol">P. Pujol</name><affiliation wicri:level="1"><nlm:aff id="aff56"><institution>Unité d'Oncogénétique, CHU Arnaud de Villeneuve</institution>, Montpellier,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff57"><institution>INSERM 896, CRCM Val d'Aurelle</institution>, Montpellier,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Coupier, I" sort="Coupier, I" uniqKey="Coupier I" first="I" last="Coupier">I. Coupier</name><affiliation wicri:level="1"><nlm:aff id="aff56"><institution>Unité d'Oncogénétique, CHU Arnaud de Villeneuve</institution>, Montpellier,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff58"><institution>Unité d'Oncogénétique, CRLCC Val d'Aurelle</institution>, Montpellier,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peyrat, J P" sort="Peyrat, J P" uniqKey="Peyrat J" first="J-P" last="Peyrat">J-P Peyrat</name><affiliation wicri:level="1"><nlm:aff id="aff59"><institution>Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret</institution>, Lille,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vennin, P" sort="Vennin, P" uniqKey="Vennin P" first="P" last="Vennin">P. Vennin</name><affiliation wicri:level="1"><nlm:aff id="aff60"><institution>Consultation d'Oncogénétique, Centre Oscar Lambret</institution>, Lille,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Muller, D" sort="Muller, D" uniqKey="Muller D" first="D" last="Muller">D. Muller</name><affiliation wicri:level="1"><nlm:aff id="aff61"><institution>Unité d'Oncogénétique, CLCC Paul Strauss</institution>, Strasbourg,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fricker, J P" sort="Fricker, J P" uniqKey="Fricker J" first="J-P" last="Fricker">J-P Fricker</name><affiliation wicri:level="1"><nlm:aff id="aff61"><institution>Unité d'Oncogénétique, CLCC Paul Strauss</institution>, Strasbourg,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Venat Bouvet, L" sort="Venat Bouvet, L" uniqKey="Venat Bouvet L" first="L" last="Venat-Bouvet">L. Venat-Bouvet</name><affiliation wicri:level="1"><nlm:aff id="aff62"><institution>Department of Medical Oncology, Centre Hospitalier Universitaire Dupuytren</institution>, Limoges,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Johannsson, O Th" sort="Johannsson, O Th" uniqKey="Johannsson O" first="O Th" last="Johannsson">O Th Johannsson</name><affiliation wicri:level="1"><nlm:aff id="aff63"><institution>Department of Oncology, Landspitali University Hospital</institution>, Reykjavik,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff64"><institution>Faculity of Medicine, University of Iceland</institution>, Reykjavik,<country>Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Isaacs, C" sort="Isaacs, C" uniqKey="Isaacs C" first="C" last="Isaacs">C. Isaacs</name><affiliation wicri:level="1"><nlm:aff id="aff65"><institution>Department of Medicine and Oncology, Georgetown University</institution>, Washington, DC,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schmutzler, R" sort="Schmutzler, R" uniqKey="Schmutzler R" first="R" last="Schmutzler">R. Schmutzler</name><affiliation wicri:level="1"><nlm:aff id="aff66"><institution>Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne</institution>, Cologne,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wappenschmidt, B" sort="Wappenschmidt, B" uniqKey="Wappenschmidt B" first="B" last="Wappenschmidt">B. Wappenschmidt</name><affiliation wicri:level="1"><nlm:aff id="aff66"><institution>Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne</institution>, Cologne,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Meindl, A" sort="Meindl, A" uniqKey="Meindl A" first="A" last="Meindl">A. Meindl</name><affiliation wicri:level="1"><nlm:aff id="aff67"><institution>Department of Gynaecology and Obstetrics, Ludwig-Maximillians University Munich</institution>, Munich,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Arnold, N" sort="Arnold, N" uniqKey="Arnold N" first="N" last="Arnold">N. Arnold</name><affiliation wicri:level="1"><nlm:aff id="aff68"><institution>Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University</institution>, Kiel,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Varon Mateeva, R" sort="Varon Mateeva, R" uniqKey="Varon Mateeva R" first="R" last="Varon-Mateeva">R. Varon-Mateeva</name><affiliation wicri:level="1"><nlm:aff id="aff69"><institution>Institute of Human Genetics, Campus Virchov Klinikum</institution>, Charite Berlin,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Niederacher, D" sort="Niederacher, D" uniqKey="Niederacher D" first="D" last="Niederacher">D. Niederacher</name><affiliation wicri:level="1"><nlm:aff id="aff70"><institution>Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University</institution>, Düsseldorf,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sutter, C" sort="Sutter, C" uniqKey="Sutter C" first="C" last="Sutter">C. Sutter</name><affiliation wicri:level="1"><nlm:aff id="aff71"><institution>Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg</institution>, Heidelberg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deissler, H" sort="Deissler, H" uniqKey="Deissler H" first="H" last="Deissler">H. Deissler</name><affiliation wicri:level="1"><nlm:aff id="aff72"><institution>Department of Gynaecology and Obstetrics, University Hospital</institution>, Ulm,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Preisler Adams, S" sort="Preisler Adams, S" uniqKey="Preisler Adams S" first="S" last="Preisler-Adams">S. Preisler-Adams</name><affiliation wicri:level="1"><nlm:aff id="aff73"><institution>Institute of Human Genetics, University of Münster</institution>, Münster,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Simard, J" sort="Simard, J" uniqKey="Simard J" first="J" last="Simard">J. Simard</name><affiliation wicri:level="1"><nlm:aff id="aff74"><institution>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University</institution>, Quebec,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Soucy, P" sort="Soucy, P" uniqKey="Soucy P" first="P" last="Soucy">P. Soucy</name><affiliation wicri:level="1"><nlm:aff id="aff74"><institution>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University</institution>, Quebec,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Durocher, F" sort="Durocher, F" uniqKey="Durocher F" first="F" last="Durocher">F. Durocher</name><affiliation wicri:level="1"><nlm:aff id="aff74"><institution>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University</institution>, Quebec,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chenevix Trench, G" sort="Chenevix Trench, G" uniqKey="Chenevix Trench G" first="G" last="Chenevix-Trench">G. Chenevix-Trench</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Genetics and Population Health Division, Queensland Institute of Medical Research</institution>, Brisbane,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Beesley, J" sort="Beesley, J" uniqKey="Beesley J" first="J" last="Beesley">J. Beesley</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Genetics and Population Health Division, Queensland Institute of Medical Research</institution>, Brisbane,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, X" sort="Chen, X" uniqKey="Chen X" first="X" last="Chen">X. Chen</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Genetics and Population Health Division, Queensland Institute of Medical Research</institution>, Brisbane,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rebbeck, T" sort="Rebbeck, T" uniqKey="Rebbeck T" first="T" last="Rebbeck">T. Rebbeck</name><affiliation wicri:level="1"><nlm:aff id="aff76"><institution>Department of Biostatistics and Epidemiology, Perelman School of Medicine and Abramson Cancer Center, University of Pennsylvania</institution>, Philadelphia, PA,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Couch, F" sort="Couch, F" uniqKey="Couch F" first="F" last="Couch">F. Couch</name><affiliation wicri:level="1"><nlm:aff id="aff77"><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff78"><institution>Department of Health Sciences Research, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, X" sort="Wang, X" uniqKey="Wang X" first="X" last="Wang">X. Wang</name><affiliation wicri:level="1"><nlm:aff id="aff77"><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lindor, N" sort="Lindor, N" uniqKey="Lindor N" first="N" last="Lindor">N. Lindor</name><affiliation wicri:level="1"><nlm:aff id="aff79"><institution>Department of Medical Genetics, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fredericksen, Z" sort="Fredericksen, Z" uniqKey="Fredericksen Z" first="Z" last="Fredericksen">Z. Fredericksen</name><affiliation wicri:level="1"><nlm:aff id="aff78"><institution>Department of Health Sciences Research, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pankratz, V S" sort="Pankratz, V S" uniqKey="Pankratz V" first="V S" last="Pankratz">V S Pankratz</name><affiliation wicri:level="1"><nlm:aff id="aff78"><institution>Department of Health Sciences Research, Mayo Clinic</institution>, Rochester, MN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peterlongo, P" sort="Peterlongo, P" uniqKey="Peterlongo P" first="P" last="Peterlongo">P. Peterlongo</name><affiliation wicri:level="1"><nlm:aff id="aff80"><institution>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predicted Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT)</institution>, Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff81"><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>, Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bonanni, B" sort="Bonanni, B" uniqKey="Bonanni B" first="B" last="Bonanni">B. Bonanni</name><affiliation wicri:level="1"><nlm:aff id="aff82"><institution>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia</institution>, Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fortuzzi, S" sort="Fortuzzi, S" uniqKey="Fortuzzi S" first="S" last="Fortuzzi">S. Fortuzzi</name><affiliation wicri:level="1"><nlm:aff id="aff83"><institution>82-IFOM, Fondazione Istituto FIRC di Oncologia Molecolare and 84-Cogentech Cancer Genetic Test Laboratory</institution>, Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peissel, B" sort="Peissel, B" uniqKey="Peissel B" first="B" last="Peissel">B. Peissel</name><affiliation wicri:level="1"><nlm:aff id="aff84"><institution>Unit of Medical Genetics, Department of Preventive and Preventive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT)</institution>, Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Szabo, C" sort="Szabo, C" uniqKey="Szabo C" first="C" last="Szabo">C. Szabo</name><affiliation wicri:level="1"><nlm:aff id="aff85"><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine</institution>, Rochester, MN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mai, P L" sort="Mai, P L" uniqKey="Mai P" first="P L" last="Mai">P L Mai</name><affiliation wicri:level="1"><nlm:aff id="aff86"><institution>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services</institution>, 6120 Executive Boulelvard, Rockville, MD 20852,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Loud, J T" sort="Loud, J T" uniqKey="Loud J" first="J T" last="Loud">J T Loud</name><affiliation wicri:level="1"><nlm:aff id="aff86"><institution>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services</institution>, 6120 Executive Boulelvard, Rockville, MD 20852,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lubinski, J" sort="Lubinski, J" uniqKey="Lubinski J" first="J" last="Lubinski">J. Lubinski</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>, Szczecin,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">British Journal of Cancer</title><idno type="ISSN">0007-0920</idno><idno type="eISSN">1532-1827</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background:</title><p>The variable penetrance of breast cancer in <italic>BRCA1/2</italic> mutation carriers suggests that other genetic or environmental factors modify breast cancer risk. Two genes of special interest are prohibitin (<italic>PHB</italic>) and methylene-tetrahydrofolate reductase (<italic>MTHFR</italic>), both of which are important either directly or indirectly in maintaining genomic integrity.</p></sec><sec><title>Methods:</title><p>To evaluate the potential role of genetic variants within <italic>PHB</italic> and <italic>MTHFR</italic> in breast and ovarian cancer risk, 4102 <italic>BRCA1</italic> and 2093 <italic>BRCA2</italic> mutation carriers, and 6211 <italic>BRCA1</italic> and 2902 <italic>BRCA2</italic> carriers from the Consortium of Investigators of Modifiers of <italic>BRCA1</italic> and <italic>BRCA2</italic> (CIMBA) were genotyped for the <italic>PHB</italic> 1630 C>T (rs6917) polymorphism and the <italic>MTHFR</italic> 677 C>T (rs1801133) polymorphism, respectively.</p></sec><sec><title>Results:</title><p>There was no evidence of association between the <italic>PHB</italic> 1630 C>T and <italic>MTHFR</italic> 677 C>T polymorphisms with either disease for <italic>BRCA1</italic> or <italic>BRCA2</italic> mutation carriers when breast and ovarian cancer associations were evaluated separately. Analysis that evaluated associations for breast and ovarian cancer simultaneously showed some evidence that <italic>BRCA1</italic> mutation carriers who had the rare homozygote genotype (TT) of the <italic>PHB</italic> 1630 C>T polymorphism were at increased risk of both breast and ovarian cancer (HR 1.50, 95%CI 1.10–2.04 and HR 2.16, 95%CI 1.24–3.76, respectively). However, there was no evidence of association under a multiplicative model for the effect of each minor allele.</p></sec><sec><title>Conclusion:</title><p>The <italic>PHB</italic> 1630TT genotype may modify breast and ovarian cancer risks in <italic>BRCA1</italic> mutation carriers. 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McClung</name></author><author><name sortKey="Danner, Db" uniqKey="Danner D">DB Danner</name></author><author><name sortKey="Morton, Cc" uniqKey="Morton C">CC Morton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Qiu, Lx" uniqKey="Qiu L">LX Qiu</name></author><author><name sortKey="Wang, Zh" uniqKey="Wang Z">ZH Wang</name></author><author><name sortKey="Wu, Xh" uniqKey="Wu X">XH Wu</name></author><author><name sortKey="Liu, Xj" uniqKey="Liu X">XJ Liu</name></author><author><name sortKey="Wang, By" uniqKey="Wang B">BY Wang</name></author><author><name sortKey="Hu, Xc" uniqKey="Hu X">XC Hu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Danemark</li><li>Espagne</li><li>France</li><li>Grèce</li><li>Islande</li><li>Israël</li><li>Italie</li><li>Pays-Bas</li><li>Pologne</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Andrulis, I L" sort="Andrulis, I L" uniqKey="Andrulis I" first="I L" last="Andrulis">I L Andrulis</name><name sortKey="Glendon, G" sort="Glendon, G" uniqKey="Glendon G" first="G" last="Glendon">G. 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Preisler-Adams</name><name sortKey="Schmutzler, R" sort="Schmutzler, R" uniqKey="Schmutzler R" first="R" last="Schmutzler">R. Schmutzler</name><name sortKey="Sutter, C" sort="Sutter, C" uniqKey="Sutter C" first="C" last="Sutter">C. Sutter</name><name sortKey="Varon Mateeva, R" sort="Varon Mateeva, R" uniqKey="Varon Mateeva R" first="R" last="Varon-Mateeva">R. Varon-Mateeva</name><name sortKey="Wappenschmidt, B" sort="Wappenschmidt, B" uniqKey="Wappenschmidt B" first="B" last="Wappenschmidt">B. Wappenschmidt</name></country><country name="Australie"><noRegion><name sortKey="Scott, R J" sort="Scott, R J" uniqKey="Scott R" first="R J" last="Scott">R J Scott</name></noRegion><name sortKey="Beesley, J" sort="Beesley, J" uniqKey="Beesley J" first="J" last="Beesley">J. Beesley</name><name sortKey="Chen, X" sort="Chen, X" uniqKey="Chen X" first="X" last="Chen">X. Chen</name><name sortKey="Chenevix Trench, G" sort="Chenevix Trench, G" uniqKey="Chenevix Trench G" first="G" last="Chenevix-Trench">G. Chenevix-Trench</name><name sortKey="Healy, S" sort="Healy, S" uniqKey="Healy S" first="S" last="Healy">S. Healy</name></country><country name="France"><noRegion><name sortKey="Sinilnikova, O M" sort="Sinilnikova, O M" uniqKey="Sinilnikova O" first="O M" last="Sinilnikova">O M Sinilnikova</name></noRegion><name sortKey="Barjhoux, L" sort="Barjhoux, L" uniqKey="Barjhoux L" first="L" last="Barjhoux">L. Barjhoux</name><name sortKey="Belotti, M" sort="Belotti, M" uniqKey="Belotti M" first="M" last="Belotti">M. Belotti</name><name sortKey="Boutry Kryza, N" sort="Boutry Kryza, N" uniqKey="Boutry Kryza N" first="N" last="Boutry-Kryza">N. Boutry-Kryza</name><name sortKey="Caux Moncoutier, V" sort="Caux Moncoutier, V" uniqKey="Caux Moncoutier V" first="V" last="Caux-Moncoutier">V. Caux-Moncoutier</name><name sortKey="Coupier, I" sort="Coupier, I" uniqKey="Coupier I" first="I" last="Coupier">I. Coupier</name><name sortKey="Coupier, I" sort="Coupier, I" uniqKey="Coupier I" first="I" last="Coupier">I. Coupier</name><name sortKey="Fricker, J P" sort="Fricker, J P" uniqKey="Fricker J" first="J-P" last="Fricker">J-P Fricker</name><name sortKey="Mazoyer, S" sort="Mazoyer, S" uniqKey="Mazoyer S" first="S" last="Mazoyer">S. Mazoyer</name><name sortKey="Muller, D" sort="Muller, D" uniqKey="Muller D" first="D" last="Muller">D. Muller</name><name sortKey="Peyrat, J P" sort="Peyrat, J P" uniqKey="Peyrat J" first="J-P" last="Peyrat">J-P Peyrat</name><name sortKey="Pujol, P" sort="Pujol, P" uniqKey="Pujol P" first="P" last="Pujol">P. Pujol</name><name sortKey="Pujol, P" sort="Pujol, P" uniqKey="Pujol P" first="P" last="Pujol">P. 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Van Den Ouweland</name><name sortKey="Van Der Luijt, R B" sort="Van Der Luijt, R B" uniqKey="Van Der Luijt R" first="R B" last="Van Der Luijt">R B Van Der Luijt</name></country><country name="Islande"><noRegion><name sortKey="Johannsson, O Th" sort="Johannsson, O Th" uniqKey="Johannsson O" first="O Th" last="Johannsson">O Th Johannsson</name></noRegion><name sortKey="Johannsson, O Th" sort="Johannsson, O Th" uniqKey="Johannsson O" first="O Th" last="Johannsson">O Th Johannsson</name></country><country name="Canada"><noRegion><name sortKey="Simard, J" sort="Simard, J" uniqKey="Simard J" first="J" last="Simard">J. Simard</name></noRegion><name sortKey="Durocher, F" sort="Durocher, F" uniqKey="Durocher F" first="F" last="Durocher">F. Durocher</name><name sortKey="Soucy, P" sort="Soucy, P" uniqKey="Soucy P" first="P" last="Soucy">P. Soucy</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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